UJI STABILITAS FISIK DAN PENETAPAN KADAR FENOLIK SEDIAAN KRIM EKSTRAK ETANOL HERBA BANDOTAN (Ageratum conyzoides L.)

Abstract

Bandotan (Ageratum conyzoides L.) is a wild plant that grows quickly and thrives in various types of soil. Bandotan contains various metabolite compounds, one of which is phenolic compounds. This study aims to obtain a stable cream preparation by varying the concentration of stearic acid and triethanolamine (TEA) to obtain an optimal formulation. The cream was formulated with varying concentrations of stearic acid of 18%, 19%, and 20%, and TEA of 3%, 2.5%, and 2%. Stability evaluation was carried out using the cycling test method which includes organoleptic tests, homogeneity, pH, adhesiveness, spreadability and viscosity. The results showed that the ethanol extract of bandotan herb containing phenolic compounds with all variations of stearic acid and TEA concentrations met the test requirements and did not show differences in organoleptic, homogeneity, pH, adhesiveness, spreadability and viscosity. Statistical test results indicate that the cream preparation is physically stable, as there was no significant difference between the cream preparation before and after the cycling test, but there was a significant decrease in phenolic content.